Detoxification
The set of processes by which the liver and kidneys transform and eliminate unwanted substances, a permanent function of the body that no diet plan can switch on.
Detoxification is a real and permanent biological function. It takes place mainly in the liver, in two phases: a transformation phase involving cytochrome P450 enzymes, then a conjugation phase that makes compounds soluble so they can be eliminated. The kidneys, gut, lungs and skin complete the system.
This system never stops and does not need to be triggered. This is the central point: there is no plan, juice or supplement capable of “activating” a detox that is already running continuously. The idea of a body accumulating toxins for lack of periodic cleansing corresponds to no physiological reality.
What these metabolic pathways do need is cofactors to work: B vitamins, magnesium, zinc, selenium, molybdenum, and sulphur-containing amino acids. A varied diet supplies them. Certain plant compounds, such as the glucosinolates in cruciferous vegetables, modulate the activity of these enzymes.
The paradox of detox plans is that they often work against their stated aim: very low in protein and micronutrients, they deprive the liver of precisely the cofactors it needs. What really supports these functions is more mundane: limit alcohol, drink enough, eat a varied diet and sleep.